Although it has long been recognized that physical exercise is good for some diabetics, it has not been known what physiological changes take place in the diabetic which promote improved health. After many months of research review by the writers, it is now believed that observed enhancements in wound healing can be explained by the effect of increased flow rates of blood upon blood rheology, and specifically, the platelet aggregation enhancing factor and intermittent capillary inversion phenomenon. Another possible explanation for the observed enhancement of wound healing in diabetics is through increasing the rate of flow of lymphatic fluids. The contracting muscle enables the lymphatic system to more speedily remove bacteria from the tissue due to this increase in flow. Until now other neuromuscular stimulators have not been effective for its clinical application due to two primary reasons. First, the degree of muscle contraction was not adequate to significantly increase flow rates of blood. Secondly, due to discomfort, the tolerance level of the great majority of these devices was low and could not be used for long enough periods of time by the patient to cause an observable change in the patient's status.

The Neuro Care 1000™, does achieve a high level of muscle recruitment by contracting those deep-layered muscles in the peroneal and tibial areas - the flexor digitorum longus, the flexor hallicus longus, the peroneus longus, and the tiila posterior. These deep muscle contractions cause greatly increased flow rates (both lymphatic fluids and blood) in the tibioperoneal trunk, the peroneal artery, the posterior tibial artery resulting in dramatic increases in flow to the smaller subdivisions of the vascular tree - the arterioles, and the venules. Likewise, the small muscles of the foot, which are deeply sheathed by synovial tendons, contract strongly, forcing blood into the arteries and into the microcirculation of the feet. Despite rapidly advancing research, prevention of peripheral vascular disease and peripheral neuropathy have not been accomplished. It is the assertion of these writers that a protocol using the Neuro Care 1000™ on a daily basis achieving sufficient intensity of muscle contraction and for adequate time periods, will retard the deterioration of the microvascular system.

It is also the assertion of these writers that such a treatment protocol will have a similar effect on retardation of diabetic neuropathy. Because the diabetic foot frequently has loss of sensation, it is a vulnerable foot and is especially prone to vascular disease and neuropathy. What may seem to be trivial trauma can very quickly lead to ulceration, infection, gangrene, and the ultimate event amputation. Utilization of NeuroMuscular Electronic Stimulation (NMES) for the enhancement of wound healing in diabetics by altering abnormal blood flow properties. Although it has long been recognized that physical exercise is good for some diabetics, it has not been known what physiological changes take place in the diabetic which promote improved health. After many months of research review by the writers, it is now believed that observed enhancements in wound healing can be explained by the effect of increased flow rates of blood upon blood rheology, and specifically, the platelet aggregation enhancing factor and intermittent capillary inversion phenomenon. Another possible explanation for the observed enhancement of wound healing in diabetics is through increasing the rate of flow of lymphatic fluids. The contracting muscle enables the lymphatic system to more speedily remove bacteria from the tissue due to this increase in flow. Until now other neuromuscular stimulators have not been effective for its clinical application due to two primary reasons. First, the degree of muscle contraction was not adequate to significantly increase flow rates of blood. Secondly, due to discomfort, the tolerance level of the great majority of these devices was low and could not be used for long enough periods of time by the patient to cause an observable change in the patient's status. The Neuro Care 1000™, does achieve a high level of muscle recruitment by contracting those deep-layered muscles in the peroneal and tibial areas - the flexor digitorum longus, the flexor hallicus longus, the peroneus longus, and the tiila posterior. These deep muscle contractions cause greatly increased flow rates (both lymphatic fluids and blood) in the tibioperoneal trunk, the peroneal artery, the posterior tibial artery resulting in dramatic increases in flow to the smaller subdivisions of the vascular tree - the arterioles, and the venules. Likewise, the small muscles of the foot, which are deeply sheathed by synovial tendons, contract strongly, forcing blood into the arteries and into the microcirculation of the feet. Despite rapidly advancing research, prevention of peripheral vascular disease and peripheral neuropathy have not been accomplished. It is the assertion of these writers that a protocol using the Neuro Care 1000™ on a daily basis achieving sufficient intensity of muscle contraction and for adequate time periods, will retard the deterioration of the microvascular system. It is also the assertion of these writers that such a treatment protocol will have a similar effect on retardation of diabetic neuropathy. Because the diabetic foot frequently has loss of sensation, it is a vulnerable foot and is especially prone to vascular disease and neuropathy. What may seem to be trivial trauma can very quickly lead to ulceration, infection, gangrene, and the ultimate event amputation.

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